創新與研究
我們的牙齒不斷地受到大量侵害，包括酸性食物和飲品，而且每天因咀嚼、刷牙和無意識的磨牙所產生的壓力，亦會令牙齒受損。結果，牙齒便會出現微細小孔，琺瑯質亦變得越來越薄。今天，這些牙齒問題已相當普遍，為了避免牙痛和接受收費高昂的牙科治療，我們需要進一步研究創新的牙科護理產品。 您可在這裡了解有關創新活性成份仿天然琺瑯質微粒(hydroxyapatite/BioHAP)的研究和其功效的更多資訊，並在我們的地圖上查看Dr. Wolff 的研究網絡。
牙齒侵蝕：一個常見的問題
歐洲的研究顯示，幾乎三分之一的人口都面對牙齒侵蝕問題¹，而且一般人難以察覺。有汽飲品或汽水、柑橘類水果或果汁中的酸性物質，都會耗損琺瑯質並導致侵蝕，令到琺瑯質被分解。
琺瑯質會變得越來越薄和透明。日積月累下，由於具有保護作用的琺瑯質流失（特別在齦緣（牙齦邊緣）），因而令牙齒的外觀開始缺乏光澤，同時在咬蘋果或喝冷水時會產生痛楚。
創新和有效的口腔護理概念：在刷牙時重新形成一層琺瑯質，從此告別琺瑯質耗損
我們能否阻止琺瑯質自然耗損？雖然人體無法自行修復已流失的琺瑯質，可是科學家已運用仿生學原理，重新製造一種與人類琺瑯質非常相似的仿天然琺瑯質微粒（Hydroxyapatite／BioHAP）。就如真正的琺瑯質一樣，這種物質是由 hydroxyapatite 組成，亦即是Bioniq® 修復產品所含有的活性成份。刷牙時，仿天然琺瑯質微粒（Hydroxyapatite／BioHAP）能在牙齒上積聚，而不會被磨損。
仿天然琺瑯質微粒 (hydroxyapaptite/BioHAP) 成份能在牙齒表面上積聚，防止琺瑯質被酸性物質侵害，從而保護牙齒免受耗損。這種成份能穿透微細小孔縫並修復孔洞區域。恆常使用，琺瑯質便能得到妥善的保護，變得光滑、堅固和耐用。
Hydroxyapatite 如何發揮保護牙齒的功效
Hydroxyapatite 在保護牙齒上的背後原理已得到臨床驗證，能為我們的口腔健康帶來多種好處：
- Hydroxyapatite 能在牙齒上形成一層保護層，保護牙齒免受酸性物質侵蝕。
- 當細菌的酸性物質侵害牙齒時, hydroxyapatite 會釋放出鈣質，保護牙齒以免脫礦。
- Hydroxyapatite 能減少細菌黏附在牙齒表面，以及減低牙菌膜形成。
- Hydroxyapatite 能防止因牙頸外露而引起的牙齒敏感。
- Hydroxyapatite 能修復琺瑯質（重新再礦化），防止蛀牙。
- Hydroxyapatite 能積聚在牙齒上，使牙齒更顯亮白。
我們的口腔護理產品含有 20% 仿天然琺瑯質微粒（Hydroxyapatite／BioHAP），能夠保持牙齒健康。
Dr. Wolff 的研究
![[Translate to zh_HK:] Research at Dr. Wolff](/fileadmin/user_upload/bioniq-repair-zahnpflege.com/images/content/forschung/bioniq-repair-teaser-forschung-im-dr-wolff-labor.jpg "[Translate to zh_HK:] Research at Dr. Wolff")
自Dr. Wolff 於 1905 年成立以來，進行研究一直是公司的核心職責。這間位於畢勒費爾德的公司，致力與眾多國內和國際的獨立機構、大學醫院和牙科診所合作，並對「德國製造」的創新牙科護理技術進行研究。所有 Bioniq® 修復產品都是由德國製造。
Dr. Wolff Research Network
查看 Dr. Wolff 的網絡
點擊地圖位置，以了解更多有關個別合作研究企業的資訊
International research collaborations
Bielefeld
Dental practice of Dr Kai Zwanzig, Bielefeld
Daily dental care with HAP toothpastes prevents sensitive teeth.
Steinert, S. et al. Daily application of a toothpaste with biomimetic hydroxyapatite and its subjective impact on dentin hypersensitivity, tooth smoothness, tooth whitening, gum bleeding, and feeling of freshness. Biomimetics 5, 17 (2020).
Read studyHAP gel brightens teeth when used daily.
Steinert, S. et al. Whitening effects of a novel oral care gel with biomimetic hydroxyapatite: A 4-week observational pilot study. Biomimetics 5, 65 (2020).
Read studyReview on the prevention of inflammatory diseases with implants.
Steinert, S., Enax, J., Simader, B., Zwanzig, K. & Meyer, F. Prävention der periimplantären Mukositis. Dentale Implantologie 5, 272-275 (2020).
Read studyBraunschweig
Braunschweig Department of Health
In vivo study: gel with HAP works as a source of calcium.
Sudradjat, H., Meyer, F., Loza, K., Epple, M., Enax, J. In vivo effects of a hydroxyapatite-based oral care gel on the calcium and phosphorus levels of dental plaque. Eur. J. Dent. (2020).
Read studyBerlin
Charité Berlin
In vitro study shows: HAP remineralises dentine and enamel.
Tschoppe, P., Zandim, D. L., Martus, P. & Kielbassa, A. M. Enamel and dentine remineralization by nano-hydroxyapatite toothpastes. J. Dent. 39, 430-437 (2011).
Read studyHalle/Saale
Fraunhofer Institute Halle/Saale
HAP builds up on the teeth and makes them brighter.
Sarembe, S., Enax, J., Morawietz, M., Kiesow, A. & Meyer, F. In vitro whitening effect of a hydroxyapatite-based oral care gel. Eur. J. Dent. 14, 335-341 (2020).
Read studyDresden
University Hospital of Dresden
In situ study confirms: the active substance HAP prevents the formation of biofilm on our teeth.
Kensche, A. et al. Efficacy of a mouthrinse based on hydroxyapatite to reduce initial bacterial colonisation in situ. Arch. Oral Biol. 80, 18-26 (2017).
Read studyFrankfurt am Main
Multicentre study with the University Hospitals of Dresden, Frankfurt, Regensburg, Munich and Würzburg
Multicentre clinical study: HAP is effective in preventing caries.
Schlagenhauf, U. et al. Impact of a non-fluoridated microcrystalline hydroxyapatite dentifrice on enamel caries progression in highly caries-susceptible orthodontic patients: A randomized, controlled 6-month trial. J. Invest. Clin. Dent., (2019).
Read studyHomburg
Saarland University Hospital
Mouthwash with HAP reduces the formation of biofilm on the teeth in situ.
Hannig, C., Basche, S., Burghardt, T., Al-Ahmad, A. & Hannig, M. Influence of a mouthwash containing hydroxyapatite microclusters on bacterial adherence in situ. Clin. Oral Investig. 17, 805-814 (2013).
Read studyWürzburg
University Hospital of Münster and University Hospital of Würzburg
Multicentre clinical study: HAP toothpaste improves gum health.
Harks, I. et al. Impact of the daily use of a microcrystal hydroxyapatite dentifrice on de novo plaque formation and clinical/microbiological parameters of periodontal health. A randomized trial. PloS one 11, (2016).
Read studyRegensburg
University Hospital of Regensburg
Topic of “sensitive teeth”
In vitro study by the University Hospital of Regensburg shows occlusion of dentinal tubules with HAP.
Hiller, K.-A., Buchalla, W., Grillmeier, I., Neubauer, C. & Schmalz, G. In vitro effects of hydroxyapatite containing toothpastes on dentin permeability after multiple applications and ageing. Sci. Rep. 8, 4888 (2018).
Read studyTopic of “Mode of action of hydroxyapatite”
HAP acts as an acid buffer and source of calcium.
Cieplik, F. et al. Ca2+ release and buffering effects of synthetic hydroxyapatite following bacterial acid challenge. BMC Oral Health 20, 85 (2020).
Read studyTopic of “New active substances”
Natural citrus extract has antibacterial effect on oral biofilms.
Cieplik et al. Antimicrobial efficacy of alternative compounds for use in oral care toward biofilms from caries‐associated bacteria in vitro, Microbiology Open, 8, 4 (2018).
Read studyMulticentre study with the University Hospitals of Dresden, Frankfurt, Regensburg, Munich and Würzburg
Multicentre clinical study: HAP is effective in preventing caries.
Schlagenhauf, U. et al. Impact of a non-fluoridated microcrystalline hydroxyapatite dentifrice on enamel caries progression in highly caries-susceptible orthodontic patients: A randomized, controlled 6-month trial. J. Invest. Clin. Dent., (2019).
Read studyMunich
Multicentre study with the University Hospitals of Dresden, Frankfurt, Regensburg, Munich and Würzburg
Multicentre clinical study: HAP is effective in preventing caries.
Schlagenhauf, U. et al. Impact of a non-fluoridated microcrystalline hydroxyapatite dentifrice on enamel caries progression in highly caries-susceptible orthodontic patients: A randomized, controlled 6-month trial. J. Invest. Clin. Dent., (2019).
Read studyMünster
University Hospital of Münster and University Hospital of Würzburg
Multicentre clinical study: HAP toothpaste improves gum health.
Harks, I. et al. Impact of the daily use of a microcrystal hydroxyapatite dentifrice on de novo plaque formation and clinical/microbiological parameters of periodontal health. A randomized trial. PloS one 11, (2016).
Read studyEssen
University of Duisburg-Essen
Review on modern dental care.
Epple, M. & Enax, J. Moderne Zahnpflege aus chemischer Sicht. Chem. Unserer Zeit 52, 218-228 (2018). [English translation: Epple, M. & Enax, J. The chemistry of dental care (Parts 1-3). ChemViews Mag. (2018).]
Read studyReview-article on abrasives used in oral care
Enax J. & Epple, M. Die Charakterisierung von Putzkörpern in Zahnpasten. Dtsch. Zahnärztl. Z. 73, 116-124, (2018).
Read studyDüsseldorf
Max Planck Institute Düsseldorf
HAP builds up on the tooth and forms a protective layer.
Fabritius-Vilpoux, K., Enax, J., Herbig, M., Raabe, D. & Fabritius, H.-O. Quantitative Affinity Parameters of Synthetic Hydroxyapatite and Enamel Surfaces in vitro. Bioinspir. Biomim. Nan. 8, 141-153 (2019).
Read studyU.S.A.
Renowned cariologist Prof B.T. Amaechi and colleagues at the UT Health San Antonio, Texas, USA
HAP gel is just as effective at remineralisation as a highly concentrated fluoride gel.
Amaechi, B. T. et akl. Comparison of hydroxyapatite and fluoride oral care gels for remineralization of initial caries: a pH-cycling study. BDJ Open 6, 9 (2020).
Read studyToothpaste with HAP remineralises caries deep down
Amaechi, B. T. et al. Comparative efficacy of a hydroxyapatite and a fluoride toothpaste for prevention and remineralization of dental caries in children. BDJ Open 5, 18 (2019).
Read studyThe Netherlands
Dentist Dr Barbara Simader, the Netherlands
Review on the prevention of inflammatory diseases with implants.
Steinert, S., Enax, J., Simader, B., Zwanzig, K. & Meyer, F. Prävention der periimplantären Mukositis. Dentale Implantologie 5, 272-275 (2020).
Read studyReview on active substances in toothpastes and mouthwashes.
Meyer, F., Enax, J. & Simader, B. Können wir dank Mundspülungen auf das Zähneputzen verzichten? Dental Tribune 6, 18-19 (2019).
Read studyPoland
Polish research team with American and German partners
One-year multicentre clinical study confirms: Children’s toothpaste with BioHAP is just as effective at protecting against caries as a fluoride toothpaste.
Steinert, S., Enax, J., Simader, B., Zwanzig, K. & Meyer, F. Prävention der periimplantären Mukositis. Dentale Implantologie 5, 272-275 (2020).
Read study很多國內和國際科學刊物，均已證明 仿天然琺瑯質微粒(hydroxyapatite/BioHAP) 在口腔護理和預防方面的功效：
- 將外露的象牙質小管密封，從而舒緩痛楚和牙齒敏感。
- 在不影響生態平衡下，能有效控制生物膜。
- 減少牙齦出血，改善牙齦健康。
- 釋出鈣質，保護牙齒以免脫礦。
- 重新再礦化牙齒，防止蛀牙。
- 溫和地美白牙齒。
除了實驗室研究（體外）外，Dr. Wolff 亦於不同口腔條件下使用測試樣本進行研究（原位），以及對患者進行臨床研究（體內）。
您亦可能對以下內容感到興趣：
研究與科學資訊
科學研究已證實，仿天然琺琅質微粒(hydroxyapatite/BioHAP) 在作為活性成份下能帶來護理牙齒的功效。您可在這裡找到各項重要研究的編彙。
常見問題
關於 Boniq® 口腔護理產品的常見問題。
Source: Jager, D. H. J. in Dental Erosion and Its Clinical Management (ed Bennett T. Amaechi) 3-11 (Springer International Publishing, 2015).